Alphafold
AlphaFold bụ Google DeepMind AI nke na-ebu amụma ọdịdị 3D nke protein site na usoro amino-acid ha, nnukwu ihe ịma aka afọ 50 na bayoloji.
Nchịkọta
Ihe ịga nke ọma ya nwetara òkè nke 2024 Nobel Prize in Chemistry.
Ime miri emi
Protein bụ agbụ nke amino acids na-agbakọta n'ụdị 3D gbagwojuru anya, na ọdịdị ahụ na-ekpebi ihe protein na-eme, site na ibu oxygen gaa na ịlụso ọrịa ọgụ. Ịkọ amụma n'ogige atụrụ site n'usoro naanị mere ka ndị ọkà mmụta sayensị sụọ ngọngọ ruo ọtụtụ iri afọ. N'afọ 2020, AlphaFold 2 tụrụ ogige ahụ n'anya na asọmpi CASP14, na-ebu amụma n'ụzọ ziri ezi na-agba ọsọ ngwa ngwa, ụzọ ụlọ nyocha dị oke ọnụ dị ka X-ray crystallography. DeepMind weputara ihe owuwu ihe karịrị nde 200 buru amụma, na-ekpuchi ihe fọrọ nke nta ka ọ bụrụ protein ọ bụla a ma ama, nweere onwe ya nye ndị nyocha. Na 2024, AlphaFold 3 gbatịpụrụ amụma ka protein si emekọrịta na DNA, RNA, ọgwụ na ụmụ irighiri ihe ndị ọzọ. Demis Hassabis na John Jumper kesara ihe nrite 2024 Nobel na Chemistry maka ọrụ ahụ.
Nghọta nka nka
AlphaFold 2 na-eji mmụta miri emi nwere ihe dabere na nlebara anya. Ọ na-enyocha 'ọtụtụ usoro nhazi', protein ndị metụtara evolushọn n'ofe ụdị dị iche iche, iji chọpụta nke amino asịd na-etolite na ya mere ọ ga-adị nso na oghere 3D. Otu modul a na-akpọ Evoformer na-agwakọta usoro yana ozi anya ụzọ abụọ, na modul nhazi wee wulite nhazi 3D doro anya. AlphaFold 3 dochie akụkụ nke nke a jiri igwe na-agbasa mgbasa nke na-ebu amụma ọnọdụ atọm maka protein na ndị mmekọ ha.
Mmetụta atụmatụ
Atụmatụ ndị na-ere ahịa
Ụzọ ndị na-ere ahịa na-emetụta atụmatụ ndị otu gị nwere ike ịrụ na-esote.
Ọnụ ego na mmefu ego
Usoro azụmahịa na nhọrọ mbugharị na-emetụta ọnụ ahịa ogologo oge yana ihe egwu.
Ihe ize ndụ na nchekwa
Ihe mkpali ụlọ ọrụ na-akpụzi ndabara ngwaahịa, ọnọdụ nchekwa, na oghere.
Ọdịnihu nke AlphaFold
AlphaFold na-eme ka nchọpụta ọgwụ na-eme ngwa ngwa, imepụta enzyme, na nghọta nke ọrịa dịka ịba na mgbochi ọgwụ nje. Ntụziaka ga-eme n'ọdịnihu na-agụnye ibu amụma mgbanwe na mmegharị protein, ọ bụghị naanị ihe onyonyo kwụ ọtọ, imezi nnukwu ogige molekụla, yana njikọta siri ike na data nnwale. Mepee ọdụ data na ntụgharị dị ka Isomorphic Labs chọrọ ịtụgharị amụma nhazi ka ọ bụrụ ọgwụ dị ọnụ ala karịa. Na-atụ anya amụma nhazi AI ga-abụ nzọụkwụ mbụ a na-eme na ihe fọrọ nke nta ka ọ bụrụ usoro ihe ọmụmụ ihe niile.
Mmejuputa n'ezie n'ụwa
Inye ihe owuwu 3D efu maka ihe karịrị nde protein 200 nye ndị nyocha n'ụwa niile
Na-eme nchọpụta ọgwụ ngwa ngwa site n'ikpughe ka ụmụ irighiri ihe nrịba ama na-ejikọta protein ezubere iche
Na-enyere aka imepụta enzymes ọhụrụ, gụnyere ndị na-akụda ihe mkpofu rọba
Na-enyere aka nyocha banyere ịba, ọrịa Parkinson, na mgbochi ọgwụ nje site na ịdepụta protein ndị dị mkpa
Ihe ize ndụ & okporo ụzọ nche
Mwepụta ọkwa nwere ike karịa nkwụsi ike na usoro nrụpụta n'ezie.
Ọnụ ahịa API ma ọ bụ mgbanwe amụma nwere ike imebi echiche n'otu abalị.
Ndabere otu onye na-ere ahịa na-abawanye mkpọchi na ọnụ ahịa mbugharị.
Map mmejuputa
Nyochaa ndị na-eweta ọrụ site na iji ọrụ nke gị na nhazi data.
Nyochaa nzuzo, nchekwa na usoro iwu tupu njikọta.
Jikwaa atụmatụ ọdịda n'ofe ụdị ma ọ bụ ndị na-ere ahịa.
Nyochaa ndetu mwepụta ka mgbanwe map ụzọ ghara iju ndị otu anya.
Nọgide na-eme nchọpụta
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Kedu ihe bụ AlphaFold?
AlphaFold bụ Google DeepMind AI nke na-ebu amụma ọdịdị 3D nke protein site na usoro amino-acid ha, nnukwu ihe ịma aka afọ 50 na bayoloji. Ọganihu ya nwetara òkè nke 2024 Nobel Prize na Chemistry.
Kedu ihe AlphaFold na-ebu amụma?
AlphaFold na-ebu amụma ka protein si agbakọ n'ụdị 3D ya dabere na usoro amino acid ya.
Gịnị kpatara ọdịdị 3D nke protein ji dị mkpa?
Udi apịaji protein na-ekpebi ihe ọ nwere ike ime, dị ka ijikọ ụmụ irighiri ihe ndị ọzọ ma ọ bụ mmeghachi omume na-akpali akpali.
N'ime mmemme 2020 ka AlphaFold 2 gosipụtara izizi ya?
AlphaFold 2 juru ndị sayensị sayensị anya na asọmpi amụma amụma protein CASP14 na 2020.
Kedu akara evolushọn ka AlphaFold 2 na-erigbu iji chọpụta nke amino acid dị nso?
Site n'ịtụle protein ndị emetụtara n'ofe ụdị, AlphaFold na-achọpụta amino asịd na-emekọ ọnụ nke nwere ike ịbịakọta ọnụ na 3D.
Kedu nnukwu nnabata ndị okike AlphaFold nwetara na 2024?
Demis Hassabis na John Jumper ketara ihe nrite 2024 Nobel na Chemistry maka AlphaFold.