Byagenze bite
NVIDIA ivuga ko yahujije ibikoresho bya BioNeMo Agent Toolkit na Anthropic ya Claude ya Claude kugirango abakozi bashobore kuvumbura no guhamagara microservices ya BioNeMo NIM. Inyandiko yacyo ya tekinike yerekana ibikorwa byakazi bigarura poroteyine zikurikirana, bikabyara ubwihindurize, bikoresha OpenFold3 na Boltz-2, kandi bikabika ibihangano byavuyemo kugirango bisuzumwe.
Inyandiko ya tekinike ya NVIDIA yo ku ya 31 Kanama isobanura BioNeMo Agent Toolkit nkigipapuro cyerekana imiterere yubumenyi bwubuzima, amasomero, hamwe nakazi gashobora kugaragara nkubuhanga-bushobora guhamagarwa. Isosiyete ivuga ko igitabo gikubiyemo ibinyabuzima, ubutabire, ibinyabuzima, no kuvumbura ibiyobyabwenge, kandi bigamije gukorana n’ibikorwa bitandukanye.
Muburyo bwerekanwe, Claude Siyanse itegura microservices eshatu NVIDIA NIM: MSA Shakisha guhuza ubwihindurize, OpenFold3 yo guhanura imiterere, na Boltz-2 kumurongo wa kabiri wo guhanura. NVIDIA ivuga ko ibipimo by'imbere byazamuye gukosora imirimo kuva kuri 60% ikagera kuri 100% kandi ikubye kabiri ibimenyetso byerekana neza; iyo mibare yatangajwe na sosiyete kandi ntabwo igeragezwa yigenga mu mwanya. Inyigisho isaba Ubumenyi bwa Claude, urufunguzo rwa NVIDIA API, no kugera ku kazi cyangwa imashini igicu hamwe na NVIDIA L40S cyangwa H100 GPU. NVIDIA igereranya hafi 700 GB yo kubika akazi, harimo hafi 490 GB kububiko bwa UniRef30 gusa na 30-40 GB kubikoresho bya Boltz-2 na OpenFold3. Inyandiko isobanura kandi ubundi buryo Claude Science ikora kuri mudasobwa igendanwa mugihe ihuza GPU ya kure binyuze muri SSH, ibikorwa remezo bya HPC, cyangwa kubara ibicu.
Inyigisho ikoresha ibikoresho bya Docker byahujwe na host GPU kandi bisaba ko hagenzurwa ubuzima mbere yuko iherezo ryemewe. Kurugero rwibinyabuzima, urujya n'uruza rugereranya poroteyine ya Seh1 C1GY11 yo muri Paracoccidioides lutzii yonyine kandi hamwe nabafatanyabikorwa, C1HCX1. NVIDIA ivuga ko umukozi yagaruye ibisigisigi 384 na 976, hanyuma agasanga 202 zikurikirana kuri poroteyine mu gihe cyo gushakisha MSA. Yashizeho uburyo budahuje umurongo wumunyururu kugiti cye hamwe nubwoko bwahujwe nubwoko bubiri. Urupapuro rwakazi rwakoresheje monomer na heteromer guhanura nta nyandikorugero, ligande, umufuka, cyangwa izindi mbogamizi zubatswe, ukoresheje ibisohoka mmCIF no kugumana ibyifuzo, ibisubizo, imiterere, ibipimo, namakosa.
Inyandiko ivuga ko OpenFold3 yatanze interineti pTM, cyangwa iPTM, ya 0.86 kuri heteromer hamwe na MSA yinjiza, naho Boltz-2 yatanze 0.82. Mubyongeyeho bitanu byintangarugero, ibipimo byavuzwe MSA-na-nta-MSA byari 0.85 na 0.14 kuri OpenFold3 na 0.82 na 0.19 kuri Boltz-2. NVIDIA ivuga ko ingero zegeranye cyane, aho gutandukana bisanzwe bitarenze 0.006, kandi ko ingengo y’imari y’icyitegererezo itigeze ihindura uburyo. Imiryango ibiri yicyitegererezo ikoresha imyubakire itandukanye kandi ikora MSA muburyo butandukanye, ariko amanota yabo ashyigikiwe na MSA yari 0.03 mugereranya ryasobanuwe.
Ibisobanuro birambuye: developer.nvidia.com ↗
Impamvu ari ngombwa
Urugero rwerekana uburyo umushakashatsi wubushakashatsi bwa AI ashobora guhuza imiterere yihariye yibinyabuzima mubikorwa byororoka aho kuvuga muri make ibitabo bya siyansi. Iratangaza kandi ko guhuza ubwihindurize byabaye ingirakamaro kuri poroteyine zahanuwe muri iki kizamini, mu gihe byerekana neza ko amasezerano y’icyitegererezo atari gihamya y’imikoranire y’ibinyabuzima.
Ubusobanuro bufatika ni orchestre layer. Gufungura poroteyine no guhanura bigoye bisaba inyongeramusaruro yihariye, imiterere yihariye yerekana imiterere, hamwe nibipimo umukozi rusange-agamije ntashobora kumenya guhitamo cyangwa gusaba. Muri konte ya NVIDIA, Ubumenyi bwa Claude bugaragaza serivisi zikenewe, butegura urutonde kandi buhuza, butangira impera, butanga ibyahanuwe, kandi bwandika ibihangano. Ibyo bituma umukozi wa AI akora umuyoboro wa siyansi, ntabwo ari uburyo bwo kuganira gusa kuri moderi imwe.
Ibisubizo birerekana kandi impamvu ubwiza bwinjiza bushobora kugira akamaro nkuguhitamo icyitegererezo. Mu kizamini cya NVIDIA, gukuraho MSA byatumye ibyiringiro bya heteromer byahanuwe bigabanuka cyane muri OpenFold3 na Boltz-2. Raporo ya OpenFold3 monomer pLDDT yagabanutse kuva kuri 82.3 hamwe na MSA igera kuri 36 itayifite, mugihe Boltz-2 agaciro kayo kavuye kuri 0.79 kagera kuri 0.73 kurwego rwa 0–1. Kugereranya byerekana ko amakuru yubwihindurize yari ingenzi cyane mugushira umubano hagati yiminyururu yombi, nubwo ibyo ari ibyiringiro biva muri serivisi zo guhanura aho gupima ibipimo nyabuzima nyabyo.
Kugereranya imiterere byongeweho hypothesis yihariye. NVIDIA ivuga ko izo moderi zombi zashyize itsinda rya beta ya C1HCX1 hafi y’uruhande rufunguye rwa Seh1 ya WD40 ya beta, ku mwanya ujyanye no gufunga icyuma cya nyuma. Kurenza ibice bya Seh1 bivugwa ko byabyaye C-alpha RMSDs ya 0,68 angstrom kuri OpenFold3 na 0,65 angstrom kuri Boltz-2 hejuru yumunyururu. Isosiyete isobanura ibi nkumufatanyabikorwa urangiza inshuro ihari aho kuyivugurura cyane. Amasezerano hagati yuburyo bwigenga bwo kubara atuma geometrike yatanzwe iba ingirakamaro nkintego yiperereza, ariko ntibisobanura ko poroteyine zihuza ingirabuzimafatizo cyangwa gukora umurimo uteganijwe hamwe.
Uburyo bukoreshwa: Uburyo bukora
Shakisha ikoranabuhanga ryihishe inyuma yiri terambere.
crm_get_transaction(id='4092').An agent must create a draft calendar event for Tuesday at 2 p.m. Which evidence would establish the requested result?
Ibyo kureba
Ibibazo nyamukuru bifunguye ni ukumenya niba akazi gakorwa muri rusange kurenza poroteyine imwe, uko bisaba nigihe bifata kugirango ukore, kandi niba ubushakashatsi bwa laboratoire bwemeza ishyirahamwe ryahanuwe. NVIDIA ivuga ibipimo ngenderwaho byimbere hamwe n amanota yicyizere cyicyitegererezo, ariko inyandiko ntabwo itanga kwigana kwigenga, gupima igihe, cyangwa kwemeza ubushakashatsi.
Imipaka igaragara neza ni ibinyabuzima byemewe. NVIDIA ivuga yeruye ivuga ko akazi kahanura imikoranire ya C1GY11 - C1HCX1 kandi ko ibisubizo bitigeze bigenzurwa mubigeragezo. Urugero rusunikwa nubushakashatsi bwibanze burimo Seh1 numufatanyabikorwa wa Mio-umuryango, ariko iyi nyandiko ubwayo ivuga isesengura ryo kubara.
Ibikorwa byo gukurikirana byakenera ibimenyetso bya laboratoire, nkibizamini bya biohimiki cyangwa selile, kugirango hamenyekane niba ishyirahamwe ryahanuwe rihari kandi niba rifite uruhare rwibinyabuzima. Kuba rusange nabyo ntibikemutse. Imyiyerekano yibanze kuri poroteyine imwe yo mu bwoko bumwe bw’ibihumyo, umwirondoro umwe wa UniRef30, hamwe n’ubushakashatsi bwakozwe hamwe n’icyitegererezo. Impinduka z’icyizere zavuzwe zerekana ko MSAs yari ifite imitwaro muri uru rubanza, ariko ntibagaragaza ko poroteyine zose zunguka ku rugero rumwe cyangwa ko amanota menshi yo mu rwego rwo hejuru ateganya rwose guhuza poroteyine zitandukanye.
NVIDIA imbere yimirimo yimbere-ikosora hamwe nimibare-yerekana neza nayo ibura ibisobanuro byerekana ibipimo ngenderwaho, ibizamini, ibigereranyo fatizo, hamwe nisuzuma ryigenga rikenewe kugirango risuzume ibisobanuro byagutse. Ibisobanuro birambuye bizagaragaza niba ibi byakoreshwa hanze yerekana. Inyandiko isaba ububiko bwibanze bwibanze, buhuza NVIDIA GPUs, gukuramo kontineri, urufunguzo rwa API, no kwemeza intoki kurangiza.
Ivuga ko ibipimo byogukora byari bihari ariko byubusa kubikorwa byatangajwe, abasomyi rero ntibashobora kumenya ubukererwe, gukoresha ingufu, igiciro cyigicu, cyangwa ibicuruzwa. Boltz-2 na OpenFold3 nayo itanga agaciro kizere kumunzani itandukanye kandi ikagaragaza imirima itandukanye, igabanya kugereranya imibare. Ibimenyetso bizakurikiraho byasubirwamo byakozwe nabashakashatsi bo hanze, ibipimo byapimwe byapimwe, ibizamini bya poroteyine nini, hamwe no kwemeza ubushakashatsi bwa hypothesis.