Overview
Insitro inosanganisa hombe-yemunhu genetic uye cellular data nekudzidza muchina kuti uwane zvirinani zvinonangwa zvinodhaka uye varwere vangango pindura. Izvo zvine basa nekuti zvinobata chikonzero chikuru chezvinodhaka kukundikana - kutora chinangwa chisiri icho - nekuita kuwanikwa mubiology yemunhu.
Insitro Machine Kudzidza Biology inonzwisiswa zvakanyanya mumamiriro ehurongwa, kuwana modhi, sarudzo dzepuratifomu, uye ecosystem kudyidzana.
Deep Dive
Yakatangwa muna 2018 nekombuta biologist uye aimbove Stanford uye mutungamiri weCoursera Daphne Koller, Insitro yakazvivaka se "muchina kudzidza-kutanga" kambani yekutsvaga zvinodhaka. Pfungwa yaro yepakati ndeyekugadzira yakakura, yakavakirwa-yakavakirwa dhatabheti-mumba - uchishandisa vanhu stem-cell-yakatorwa ('in vitro') mhando dzechirwere, kufungidzira-kugutsikana, uye 'omics zviyero - uye kuzvibatanidza nehukuru hwevanhu genetic uye kiriniki cohorts seUK Biobank. Kudzidza kwemuchina kunobva kwabatanidza masiginecha emamorekuru nemaserura kuchirwere, zvichibatsira kuona zvinangwa izvo genetics inoratidza kuti zvinokonzeresa kurwara, uye kuisa varwere mumapoka madiki. Iro zita pacharo rinosanganisa 'mu silico' (computation) uye 'in vitro' (lab biology). Insitro yakabatana neGiriyedhi neBristol Myers Squibb uye inotarisa munzvimbo dzakaita semetabolism, chiropa, uye neurodegenerative chirwere.
Technical Insight
Siginecha Insitro nzira inoshandisa muchina kudzidza pamifananidzo yezvokurapa - semuenzaniso, mamodheru akadzama achiverenga chiropa MRI kana histopathology - kutora huwandu 'muchina-kudzidza phenotypes.' Kumhanya genome-wide association zvidzidzo zvichipesana neaya eAI-akabva hunhu mukati mebiobank-scale vanhu vanogona kutarisana nemajini akasiyana, uye nekudaro zvinokonzeresa zvinangwa, izvo zvisina hunhu zvekiriniki zvinyorwa zvinopotsa. Izvi zvinobatanidza genetics yemunhu, humbowo hwakasimba hwekuti chinangwa chakakosha, chine hupfumi hwe phenotypic resolution kubva kuAI.
Mastering Insitro Machine Kudzidza Biology
Insitro inosanganisa hombe-yemunhu genetic uye cellular data nekudzidza muchina kuti uwane zvirinani zvinonangwa zvinodhaka uye varwere vangango pindura. Izvo zvine basa nekuti zvinobata chikonzero chikuru chezvinodhaka kukundikana - kutora chinangwa chisiri icho - nekuita kuwanikwa mubiology yemunhu. Insitro Machine Kudzidza Biology inonzwisiswa zvakanyanya mumamiriro ehurongwa, kuwana modhi, sarudzo dzepuratifomu, uye ecosystem kudyidzana. Kuvaka kunzwisisa kwakadzama, tora Insitro Machine Kudzidza Biology semuenzaniso wekushandisa, kwete chinhu chimwe chete: tsanangura zvinodiwa, kujekesa fungidziro, uye patsanura izvo zvinogona kuitwa nehurongwa hwakavimbika kubva kune zvichiri kuda kutonga kwenyanzvi.
Mukuita, zvikwata zvakasimba zvinoshandisa Insitro Machine Kudzidza Biology inoongorora zano revatengesi, kuvimbika kwemepu yemugwagwa, uye njodzi yekuvhara isati yaita. Ivo vanonyora zvakajeka maitiro ebudiriro, bvunzo vachipokana ne data rechokwadi uye mafambiro ebasa, uye iterate zvichibva pane zvakacherechedzwa maitiro ekutadza kwete kuhwina-nguva imwe chete yebhenji. Apa ndipo apo kunzwisisa kwe theoretical kunoshanduka kuve kugona kwakasimba pane chigadzirwa, mutemo, uye mashandiro.
Mamepu emigwagwa emutengesi anopesvedzera izvo izvo timu yako inogona kugadzira inotevera. Panguva imwecheteyo, zviziviso zveLaunch zvinogona kupfuura kugadzikana mune chaiyo yekugadzira workflows. Nzira yakatsiga ndeyekubatanidza kukurumidza kuyedza nekutonga: mhanyisa vatyairi vendege, tora humbowo, buritsa matanda esarudzo, uye urambe uchivandudza chengetedzo semaitiro emuenzaniso, zvinotarisirwa nemushandisi, uye zvinodikanwa zvekutonga.
Strategic Impact
Mamepu emigwagwa emutengesi anopesvedzera izvo izvo timu yako inogona kugadzira inotevera.
Mamepu emigwagwa emutengesi anopesvedzera izvo izvo timu yako inogona kugadzira inotevera. Mukutumirwa kwemhando yepamusoro, izvi zvinoshandurirwa kuita mitemo inoyerwa yekushanda, miganhu yevaridzi, uye tsika dzekudzokorora dzinodzokororwa kuitira kuti zvikwata zvikwire kuvimba pane kukwidza kusajeka.
Mamiriro ezvekutengeserana uye sarudzo dzekuendesa dzinokanganisa mutengo wenguva refu uye njodzi.
Mamiriro ezvekutengeserana uye sarudzo dzekuendesa dzinokanganisa mutengo wenguva refu uye njodzi. Mukutumirwa kwemhando yepamusoro, izvi zvinoshandurirwa kuita mitemo inoyerwa yekushanda, miganhu yevaridzi, uye tsika dzekudzokorora dzinodzokororwa kuitira kuti zvikwata zvikwire kuvimba pane kukwidza kusajeka.
Kambani inokurudzira inogadzirisa kusarudzika kwechigadzirwa, mamiriro ekuchengetedza, uye kuvhurika.
Kambani inokurudzira inogadzirisa kusarudzika kwechigadzirwa, mamiriro ekuchengetedza, uye kuvhurika. Mukutumirwa kwemhando yepamusoro, izvi zvinoshandurirwa kuita mitemo inoyerwa yekushanda, miganhu yevaridzi, uye tsika dzekudzokorora dzinodzokororwa kuitira kuti zvikwata zvikwire kuvimba pane kukwidza kusajeka.
Real-World Implementation
Kudzidzira mamodheru pachiropa MRI scans kuti igadzire quantitative phenotypes, wozomhanyisa genetic association zvidzidzo kutsvaga zvinodhaka zvinonangwa nechirwere chechiropa.
Kushandisa stem-cell-derived neurons kuenzanisira ALS uye zvimwe zvirwere zveurourodegenerative pakuongororwa kweML.
Kudyidzana neGiriyedhi kutsvaga zvinangwa zvenonalcoholic steatohepatitis (NASH) uye chiropa fibrosis.
Kuisa varwere muzvikamu zvemajini kuti vafanotaura kuti ndiani achapindura kurapwa kwakapihwa.
Maitiro Ekuita
Insitro Machine Kudzidza Biology mukuita
Kudzidzira mamodheru pachiropa MRI scans kuti igadzire quantitative phenotypes, wozomhanyisa genetic association zvidzidzo kutsvaga zvinodhaka zvinonangwa nechirwere chechiropa.
Kudzidzira mamodheru pachiropa MRI scans kuti igadzire quantitative phenotypes, wobva wamhanyisa genetic association zvidzidzo kutsvaga zvinodhaka zvinonangwa nechirwere chechiropa Matimu anowanzo kuwana mibairo iri nani kana achinge atsanangudza emhando yepamusoro kumberi, chengetedza nzira yekukwira kwevanhu yemakesi emupendero, uye kuteedzera zvese zvinobudirira kubudirira uye kukanganisa kwemitengo nekufamba kwenguva.
Insitro Machine Kudzidza Biology mukuita
Kushandisa stem-cell-derived neurons kuenzanisira ALS uye zvimwe zvirwere zveurourodegenerative pakuongororwa kweML.
Kushandisa stem-cell-derived neurons kuenzanisira ALS uye zvimwe zvirwere zveurourodegenerative zveML ongororo Matimu anowanzo kuwana mhedzisiro iri nani kana achinge atsanangura hunhu hwepamberi, chengetedza nzira yekukwira kwevanhu yemakesi emupendero, uye kuteedzera zvese zvakawanikwa zvechigadzirwa nemitengo yekukanganisa nekufamba kwenguva.
Insitro Machine Kudzidza Biology mukuita
Kudyidzana neGiriyedhi kutsvaga zvinangwa zvenonalcoholic steatohepatitis (NASH) uye chiropa fibrosis.
Kudyidzana neGiriyedhi kutsvaga zvinangwa zve nonalcoholic steatohepatitis (NASH) uye chiropa fibrosis Matimu anowanzo kuwana mhedzisiro iri nani kana achinge atsanangura hunhu kumberi, kuchengetedza nzira yekukwira kwevanhu yemakesi emupendero, uye kuteedzera zvese zvakawanikwa zvechigadzirwa uye mutengo wekukanganisa nekufamba kwenguva.
Insitro Machine Kudzidza Biology mukuita
Kuisa varwere muzvikamu zvemajini kuti vafanotaura kuti ndiani achapindura kurapwa kwakapihwa.
Kuisa varwere muzvikamu zvidiki zvekufanotaura kuti ndiani achapindura kurapwa kwakapihwa Matimu anowanzo kuwana mibairo iri nani kana achinge atsanangura emhando yepamusoro kumberi, chengetedza nzira yekukwira kwevanhu yemakesi ekumucheto, uye kuteedzera zvese zvakawanikwa zvechigadzirwa uye mutengo wekukanganisa nekufamba kwenguva.
Njodzi & Guardrails
Zviziviso zvekutanga zvinogona kupfuura kugadzikana mune chaiyo yekugadzira workflows.
Mitengo yeAPI kana shanduko yepolicy inogona kukanganisa fungidziro husiku.
Kutsamira kune mumwe-mutengesi kunowedzera kukiya-mukati uye mari yekufambisa.
Implementation Roadmap
Ongorora vanopa uchishandisa ako ega mabasa uye dataset.
Ongorora vanopa uchishandisa ako ega mabasa uye dataset. Bata nhanho yega yega segedhi rehumbowo: kana maitiro asina kusangana, imbomira kuburitsa, vhara gaka, uye wobva wawedzera kushandiswa.
Wongorora zvakavanzika, chengetedzo, uye mazwi emutemo usati wabatanidzwa.
Wongorora zvakavanzika, chengetedzo, uye mazwi emutemo usati wabatanidzwa. Bata nhanho yega yega segedhi rehumbowo: kana maitiro asina kusangana, imbomira kuburitsa, vhara gaka, uye wobva wawedzera kushandiswa.
Chengetedza chirongwa chekudzokera kumashure kune mamodheru kana vatengesi.
Chengetedza chirongwa chekudzokera kumashure kune mamodheru kana vatengesi. Bata nhanho yega yega segedhi rehumbowo: kana maitiro asina kusangana, imbomira kuburitsa, vhara gaka, uye wobva wawedzera kushandiswa.
Tarisa zvinyorwa zvekuburitsa kuitira kuti shanduko yemigwagwa isashamise zvikwata.
Tarisa zvinyorwa zvekuburitsa kuitira kuti shanduko yemigwagwa isashamise zvikwata. Bata nhanho yega yega segedhi rehumbowo: kana maitiro asina kusangana, imbomira kuburitsa, vhara gaka, uye wobva wawedzera kushandiswa.