AlphaFold Quiz

Answers and explanations appear as you take the quiz.

1. What does AlphaFold predict?
   • The 3D structure of a protein from its amino-acid sequence
   • The weather
   • Stock prices
   • Human faces from names
2. How can a protein’s 3D structure help researchers study its function?
   • It proves a protein’s activity without experiments
   • It can reveal the arrangement of sites and surfaces that inform hypotheses about interactions
   • It determines every effect of a protein in every cell
   • It directly measures gene expression
3. At which 2020 event did AlphaFold 2 demonstrate its breakthrough accuracy?
   • The Olympics
   • A chess tournament
   • CASP14
   • A music festival
4. What evolutionary signal does AlphaFold 2 exploit to find which amino acids are near each other?
   • Phone records
   • Satellite imagery
   • Random guessing
   • Multiple sequence alignments of related proteins
5. What major recognition did AlphaFold's creators receive in 2024?
   • A share of the Nobel Prize in Chemistry
   • An Olympic gold medal
   • A Grammy Award
   • Nothing
6. What new capability did AlphaFold 3 add in 2024?
   • Writing poetry
   • Predicting interactions with DNA, RNA, and drug molecules
   • Translating languages
   • Driving cars
7. What kinds of molecules can AlphaFold 3 model in addition to proteins?
   • Only proteins and no other molecular types
   • Only water molecules and salts
   • Interactions involving DNA, RNA, and small-molecule ligands, among other biomolecules
   • Every possible chemical reaction with experimental certainty
8. What should researchers remember when interpreting an AlphaFold prediction?
   • High confidence makes experimental validation unnecessary
   • Every predicted interaction is established fact
   • A structure prediction directly demonstrates biological function
   • It is a model prediction with confidence information, not experimental proof